Joseph Guiles

Signet Healthcare Partners LLC (Signet Healthcare Partners) is a private equity/venture capital subsidiary of Sanders Morris Harris Group Private Equity founded in 1998. The firm is headquartered in New York.

Case Western Reserve University provides educational services. It offers a variety of undergraduate degree courses and graduate and professional options such as arts and sciences, dentistry, engineering, law, management, medicine, nursing, social work, and more. The firm also offers dual-degree programs. The company was founded in 1826 and is headquartered in Cleveland, OH.

Icon Bioscience, Inc. develops and markets ophthalmic pharmaceuticals. It develops specialty pharmaceuticals targeting ophthalmic indications including macular edema, glaucoma, age-related macular degeneration and cataract surgery. The firm's pipeline includes IBI-10090, IBI-20089, IBI-60089, and IBI-80090. The company was founded by Vernon G. Wong and is headquartered in Newark, CA.

Control Delivery Systems Inc. designs, develops and manufactures drug delivery products. The products are designed to deliver precise quantities of drugs to difficult-to-treat areas of the body. The company was founded in 1991 and is headquartered in Watertown, MA.

Dow Pharmaceutical Sciences, Inc. develops and distributes topical drug products. The firm provides product development services including formulation and regulatory consulting, formulation optimization utilizing state-of-the-art in vitro permeation models, full analytical support, cGMP clinical manufacturing and clinical labeling. The company was founded by Gordon J. Dow in 1977 and is headquartered in Petaluma, CA.

ORBIS International, Inc. prevents and treats blindness by providing eye care to transform lives. It offers tools, training and technology necessary for local partners to develop eye care services. The company was founded in 1982 by David Paton and is headquartered in New York, NY.

PEAK Surgical is a medical device company that has developed the PEAK Surgery System, a new tissue dissection system based on a proprietary technology that represents an important advance in radiofrequency surgical technologies. The PEAK Surgery System consists of the PEAK PlasmaBlade, a family of disposable cutting devices that offer the exacting control of a scalpel and the bleeding control of traditional electrosurgery without extensive collateral damage, and the PULSAR Generator, which supplies pulsed plasma radiofrequency energy to the PlasmaBlade. The PEAK Surgery System is cleared for use in general, plastic and reconstructive, ENT, gynecologic, orthopedic, arthroscopic, spinal and neurological surgical procedures in the United States, and for use in general surgery in the European Union. It was launched in the United States in July 2008 and has been used by U.S. surgeons on many patients, including general, gynecologic, orthopedic and plastic and reconstructive surgeries

Valera Pharmaceuticals, Inc. develops and commercializes products for the treatment of urology and endocrine conditions, diseases and disorders. The Company was founded in 1972 and is located in Cranbury, NJ.

Fluxion Biosciences, Inc. conducts clinical research for early cancer detection and patient monitoring. It offers live cell analysis, automated patch clamping, and circulating tumor cell analysis. The company was founded by Michelle Khine, Cristian Ionescu-Zanetti, and Michael Schwartz in 2006 and is headquartered in Alameda, CA.

Pharma Nobis, LLC manufactures pharmaceutical topical, transdermal creams, and syrups products. The private company is based in Texarkana, TX.

Juno Pharmaceuticals Corp. specializes in bringing complex and high-value generic and biosimilar products to the Canadian market. The company is based in Mississauga, Canada, and has subsidiaries in Canada. The Juno management team possesses decades of pharmaceutical industry experience and has a track record of driving strategic growth through the identification of niche products and disciplined construction of robust product pipelines. Juno licenses and acquires specialized pharmaceutical products that have limited competitors and inherent barriers to market entry. The Canadian company was founded in 2019, and Mark Mantel has been the CEO of the company since 2022.

Eresearch Technologies, Inc. provides biopharmaceutical and healthcare research and drug development services.

Ascendia Pharmaceuticals LLC engages in the invention and development of specialty pharmaceutical products and novel formulation technologies. It offers rapid development and special development programs. The company was founded by Jingjun Huang in 2012 and is headquartered in North Brunswick, NJ.

Impopharma, Inc. engages in developing and testing of pulmonary and nasal drug delivery systems and ophthalmic, otic, and dermal products. The company was founded by Hanna Piskorz and Harold Wulffhart in 1996 and is headquartered in Concord, Canada.

Essential Medical, Inc. designs, develops, and markets medical and surgical devices. It specializes in vascular closure devices that seals the opening created from cardiac catheterizations in leg arteries. The company was founded by Gary S. Roubin and Greg A. Walters in 2010 and is headquartered in Wayne, PA.

Kew, Inc. provides oncology services. It provides multiple services to oncologists to assist in treatment decisions for cancer patients and offers genomic testing for patient tumor samples and genomic information important to diagnostic and treatment decisions that assist physicians and are detailed in cancer-specific Therapeutic Pathways. The company was founded by Richard Bohmer, Viren Mehta, Clayton Matt Christensen, Jeffrey Elton, Mason Freeman, John P. Glaser, H. Robert Horvitz, Bruce Johnson, Kathy Behrens Wilsey and Raju S. Kucherlapat in 2009 and is headquartered in Cambridge, MA.

ERT Operating Co. engages in the provision of centralized electrocardiographic services. It offers safety and efficacy endpoint collection, data integration and analytics, and real-world evidence. The company was founded in 1977 and is headquartered in Philadelphia, PA.

Impulse Dynamics Ltd. (US) develops implantable device for the treatment of chronic heart failure. The company is headquartered in Mount Laurel, NJ.

Contego Medical LLC develops novel emboli protection devices. Its products include CORGUARD coronary stent system, VANGUARD renal stent system, and PALADIN carotid post-dilation balloon. The company was founded by Ravish Sachar and Jay S. Yadav in 2005 and is headquartered in Raleigh, NC.

Majalin LLC (Majalin), doing business as Amzak Health, is a private equity and venture capital subsidiary of Amzak Capital Management LLC, ultimately owned by Amzak International, Inc. The firm was founded in 2015 by Joyce Erony and is headquartered in New York, NY.

Neuros Medical, Inc. develops neurostimulation therapies. It offers Altius System that consists of an implantable generator with an integrated rechargeable battery, cuff electrode, and external devices. The company was founded by Jon J. Snyder, Kevin L. Kilgore, and Niloy Bhadra in 2008 and is headquartered in Willoughby Hills, OH.

Impulse Dynamics NV develops electrical therapies for the treatment of chronic heart failure. Its product Optimizer III is designed for the treatment of patients with moderate and severe heart failure. The company was founded in 1996 and is headquartered in Willemstad, Netherlands Antilles.

KBI Biopharma, Inc. provides drug development and contract manufacturing services. It helps client partners accelerate and optimize drug development and manufacturing programs by offering an extensive suite of expert development and manufacturing services. The firm offers services to global pharmaceutical and biotechnology companies, and academic and non-profit organizations. The company was founded in 1996 and is headquartered in Durham, NC.

Advantice Health LLC manufactures and supplies therapeutic medicines and personal products. It is engaged in the marketing, sale and distribution of over-the-counter (OTC) medicines to drug stores, food stores, mass merchandisers, health professionals and international markets. It is best known for podiatrist recommended Kerasal One-Step Exfoliating Moisturizer Therapy. The company was founded in 2004 and is headquartered in Cedar Knolls, NJ.

BK Technologies, Inc. engages in the provision of two-way radio communications equipment. Its brands include BK Technologies, BK Radio and RELM. The company was founded in February 1960 and is headquartered in West Melbourne, FL.

Alpex Pharma SA develops and produces orally dispersible tablet (ODT). Its products include Alpexicam and Meloxicam ODT. The firm also provides formulation development and contract manufacturing services. The company was founded in 1985 and is headquartered in Mezzovico, Switzerland.

Sanders Morris Harris LLC (Investment Management) (SMH-IM) is the investment management division of Sanders Morris Harris LLC, a registered broker/dealer firm headquartered in Houston, Texas. The firm was founded in 2000 and is a wholly-owned subsidiary of Tectonic Financial, Inc. (NASDAQ: TECTP). SMH-IM provides advisory services to individuals, pooled investments, plan sponsors, trusts, estates, corporations, institutions, and other businesses.

CyDex Pharmaceuticals, Inc. provides pharmaceutical discovery, development and manufacturing services. Its product Captisol is a polyanionic beta-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether (SBE). The firm engages in technology with substantial characterization, safety documentation and regulatory review. The company was founded in 1990 and is headquartered in San Diego, CA.

Latshaw Enterprises, Inc. was a holding company which manufactures cable devices and electronic components. The company through its subsidiaries produced and marketed component parts for original equipment manufactures as well as consumer products. The company was founded in 1982 and headquartered in Wichita, KS.

Dr. Reddy's Research & Development BV is engaged in the development and manufacture of injectable pharmaceutical products. It provides formulation, development, drug delivery, and clinical material manufacturing services to biotech and pharmaceutical companies worldwide. The company was founded by Joost J. M. Holthuis on July 20, 1995 and is headquartered in Leiden, Netherlands.