David Sinclair

Sirtris Pharmaceuticals, Inc., a GSK company, is developing small molecule drugs that target the sirtuins, a family of seven enzymes associated with diseases of aging. Modulation of these enzymes offers the promise of drug discovery in multiple therapeutic areas. Sirtris was one of the pharmaceutical companies focused on the sirtuin platform and remains the innovative drug discovery. Preclinical research indicates that the sirtuins play important roles in pathways for multiple diseases of aging, including Type 2 Diabetes, as well as neurodegenerative, cardiovascular and inflammatory diseases. Sirtris researchers are working to translate this research into a potential new class of pharmaceuticals to treat diseases of aging, offering the ability for people to live longer, healthier lives. Sirtris has focused on developing many novel small molecule activators of SIRT1, the most studied member of the sirtuin family. These new chemical entities or NCEs are novel compounds that are chemically unrelated to resveratrol, a naturally occurring compound that was used as an early proof-of-concept for SIRT1 activation. Besides being structurally differentiated from resveratrol, the NCEs are more specific for the target SIRT1 and have improved drug-like properties. The company has completed several early stage translational clinical studies with the first generation NCEs and has several active clinical trials under way. Sirtris operates as an independent Discovery Performance Unit (DPU) within GSK and is located in Technology Square, Cambridge, Mass. Sirtris' culture mixes scientific curiosity with a dynamic, fast-paced environment, resembling its biotech roots while harnessing all of GSK's broad discovery, development, and commercialization capabilities. The company was founded in 2004 and is headquartered in Cambridge, MA.

Segterra, Inc. engages in the development and marketing of a health and fitness analytics platform. It offers InsideTracker, which tracks and analyzes key biochemical and physiological markers and applies algorithms and scientific databases to determine personalized optimal zones for each marker. The company was founded by Richard Arnstein, Gil Blander, Christina Reich and David Lester in 2009 and is headquartered in Cambrdige, MA.

OvaScience, Inc. engages in the research and development of female infertility treatments. Its portfolio includes AUGMENT, OvaPrime, OvaTure, and OvaXon which intends to improve the female's egg health and reserve. The company was founded by Rich H. Aldrich, Michelle Dipp, Jonathan L. Tilly, and Christoph H. Westphal on April 5, 2011 and is headquartered in Waltham, MA.

Jupiter Neurosciences, Inc. is a clinical stage research and development pharmaceutical company. Its therapeutic candidate, JOTROL is applicable to many central nervous system diseases, including Alzheimer’s disease and traumatic brain injury. The company was founded by Christer Rosén, Alexander Rosén, Claes Wahlestedt, Marshall Hayward, and Shaun P. Brothers in June 2015 and is headquartered in Jupiter, FL.

EdenRoc Sciences LLC engages in the business of biotechnology. The company was founded in 2016 and is headquartered in Birmingham, MI.

Continuum Biosciences, Inc. operates as a biotech company that focuses on diseases such as obesity, diabetes, and ageing. The company was founded in 2017 and is headquartered in Blacksburg, VA.